BPC-157
Body Protection Compound 157 · Pentadecapeptide BPC 157
The most-discussed repair peptide in the research literature
BPC-157 is a synthetic 15-amino-acid peptide derived from a partial sequence of a protective protein found in human gastric juice. First characterized by researchers at the University of Zagreb in the early 1990s, it has become one of the most studied peptides in preclinical injury-repair research — with a literature spanning tendon, ligament, muscle, gastrointestinal, and vascular models.
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View BPC-157 →What the Research Actually Says
Every claim below is cited to the published literature and labeled by how far the evidence has actually progressed. Numbers refer to the reference list at the bottom of the page.
Tendon & ligament healing
Preclinical (cell & animal)The best-known BPC-157 literature. In rat models of Achilles tendon detachment and ligament injury, BPC-157 administration was associated with faster, more organized healing. In vitro work suggests a mechanism: enhanced tendon fibroblast outgrowth, survival, and migration.
Gastrointestinal protection
Preclinical (cell & animal)BPC-157's original research context. Across rodent models of gastric ulcer, fistula, and inflammatory bowel injury, it showed consistent cytoprotective effects — the reason its discoverers dubbed it a 'body protection compound.'
Angiogenesis & vascular repair
Preclinical (cell & animal)Studies in injury models report that BPC-157 promotes new blood-vessel formation, with in vitro evidence pointing to VEGFR2 pathway activation — a plausible common thread behind its effects across different tissue types.
Nervous system models
Preclinical (cell & animal)A newer and smaller branch of the literature examines BPC-157 in central nervous system injury models and the brain–gut axis, summarized in a 2022 review. This work remains early even by preclinical standards.
Where the Evidence Stops
- ◆There are no published human randomized controlled trials of BPC-157. Every efficacy claim you see traces back to animal or cell studies.
- ◆Human dosing, bioavailability, and long-term safety are unestablished.
- ◆Much of the literature originates from a single research group (Sikirić and colleagues, Zagreb), which is a standard reason for scientific caution until independently replicated.
- ◆BPC-157 is prohibited in competitive sport under WADA's S0 (unapproved substances) category.
Research-grade BPC-157, batch-documented
RGP Labs ships from the US and publishes a batch number and full specifications for every vial. Code BPC10 takes 10% off — applied automatically at checkout.
Sold for laboratory research use only — not for human consumption.
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Our free guide covers BPC-157 and nine other research peptides in depth — mechanisms, the state of the evidence, safety considerations, and a supplier-vetting checklist — across 12 chapters and 140+ citations.
References
- Sikiric P, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Current Pharmaceutical Design, 2011.
- Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 2011.
- Krivic A, et al. Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: promoted tendon-to-bone healing. Journal of Orthopaedic Research, 2006.
- Gwyer D, Wragg NM, Wilson SL Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 2019.
- Hsieh MJ, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation. Journal of Molecular Medicine, 2017.
- Vukojević J, et al. Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research, 2022.
More compound profiles
Published 2026-08-12. Reviewed against the cited primary literature.
This page is for educational purposes only and is not medical advice. Peptides discussed here are research compounds; nothing here is a recommendation to use them. Consult a qualified healthcare provider about anything affecting your health.